Consortium partners

consortium-ppl 

Karolinska Institutet

Karolinska Institutet

Further Information : http://www.ki.se/

Organizational Activities

Karolinska Institutet (KI) is a medical university with internationally leading research, high quality core facilities, cutting edge research PhD and Postdoc courses and with a strong link to the Karolinska Hospital.

The Medical Inflammation Research Unit (MIR) (led by R Holmdahl) MIR is a research unit within KI focusing on chronic inflammatory diseases based on genetic analysis and in depth pathway analysis of mouse and rat models, including inflammatory neurodegenerative disease models. The resources include 150 congenic and genetically modified mouse and rat strains and a cohort of 2000 heterogeneous stock mice, The strains are selected to be of use to studies of specific mechanisms for inflammation and oxidation pathways. Genetic analyses, molecular pathways and development of therapeutic strategies are under investigation, in particular studies of how oxidation related genes control inflammation.

The Neuroimmunology Unit (NU) is a research unit within KI studying the causes and pathogenesis of Multiple Sclerosis (MS) and other neurological disorders through an integrated programme combining studies of rodent and human genetics, neurodegeneration, neuroimmunological mechanisms, basic neuroscience and development of therapies as a result of these approaches. NU has established large cohorts of patients and corresponding biobanks: 1) The EIMS cohort (1,800 incident MS cases & 2,500 controls, all with DNA, sera & plasma samples), 2)The IMSE cohort (1,300 Tysabri-treated MS, >5000 DNA and plasma). 3) The GEMS biobank, (soon 5,000 prevalent MS and 4,000 controls), all with DNAs and plasmas. 4) The STOP-MS cohort with > 500 matched cerebrospinal fluid (CSF)/Plasma samples, PBL and CSF cell samples. For the EIMS and GEMS cohorts detailed information on exposures and lifestyle is available. Cutting edge equipment and know-how for molecular genetic studies, biostatistics and immunology is available.

Role in the Project

Key Personnel

Rikard Holmdahl, MD,PhD, Professor in Medical Inflammation Research, KI. Expertise in genetics and immunology. Has experience in using animal models in translation medicine. Has deep knowledge in genetics and immunology and also validation of new therapies using animal models for MS and RA. CV details: Descartes prize 2002 for MS research and also for the best Scandinavian prizes Fernström 92, Gustafsson 94 and SalusAnsvar 03). Executive board member of Eur J of Immunol. Main supervisor for 30 and cosupervisor for 9 completed PhD. Author/co-author of >400 original papers published in peer review journals, many high impact (Nat Gen, Science, Cell, JCI, JEM, PNAS). H-index 60, in total 12000 citations.

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Tomas Olsson, MD, PhD, Professor Neurology, KI. Expertise in clinical neurology, therapeutic trials, genetics and immunology. Has a longstanding experience in experimental models for nervous system infections and autoimmune conditions, as well as human diseases with a main focus on MS.

Selected CV details: Fernströms prize for Medical research, Karolinska institute, 1994. 2010 elected as president over the International Society for Neuroimmunology (ISNI). Member of the Nobel assembly. Member of the international board of the European committee for the treatment of MS (ECTRIMS). Member of the international MS societies. Co-founder of the European school of Neuroimmunology (ESNI). Main or co-supervisor for 38 students having reached PhD degree, and advisor for 17 post docs. Author/co-author of 348 original papers published in peer review journals, many of which being in the high impact range (NEJM, Cell, Lancet, JCI, JEM, Nat Gen, Nat Biotech, PNAS, JNS, JI). Author/co-author of 45 reviews. H-index 59, a total No of citations 14900.

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Fredrik Piehl, professor, expertise in neurodegenerative aspects of neuroinflammation.

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Mohsen Khademi, Senior Post-doctoral Fellow & Lab. Management, expert in human cellular and humoral immune responses, handles the KI biobanks and human samples.

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Patrick Merky, postdoc, expertise in human cellular and humoral immune responses and ROS function of human cells

 

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Lina Olsson, postdoc, expertise in human Ncf1 genetics and ROS function of human cells

 

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Outi Sareila, postdoc (Turku), expertise in Ncf1 conditional mouse strains and Ncf1 expression studies

 

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