Consortium partners

consortium-ppl 

Université Joseph Fourier Grenoble 1

Université Joseph Fourier Grenoble 1

Further Information : http://www.ujf-grenoble.fr/

Organizational Activities

Grenoble Institut de Neurosciences (GIN) is a Joint Research Unit (JRU) between Université Joseph Fourier Grenoble 1 (UJF) and the Institut National de la Santé et de la Recherche Médicale (INSERM). Created in 2007, it employs up to 250 researchers, clinicians, engineers, technicians as well as postdoc and PhD students, to focus on brain diseases (e.g., epilepsy, Parkinson, schizophrenia, Alzheimer) in a translational and multidisciplinary way. The group of Antoine Depaulis (Dynamics of Epileptic Synchronized Networks) is internationally recognized for its expertise in the physiopathology of epilepsy and the development of chronic animal models. This group has actively participated in the validation of the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) and, more recently, has developed and characterized the model of mesiotemporal lobe epilepsy (MTLE) in the mouse. This model has allowed a Systems Biology approach of the initial phase of epileptogenesis funded by the FP6-STREP project called Valapodyn, coordinated by A. Depaulis. During NEURINOX, this group will be in charge of performing immunohistochemical labeling in animal models, collecting brain tissue from human patients, studying the consequences of microglia ablation and down regulation of NO enzymes using different strategies.

Role in the Project

Key Personnel

Antoine DEPAULIS, is an INSERM Director of Research and Group leader at the GIN. With a PhD in Neuroscience and in Pharmacology, he has a 25-year experience in animal models of epilepsy. His main expertise is on EEG recording in freely moving animals and coupling of this technique with other methods (microdialysis, fMRI, etc.). He is the author of 123 publications in peer-reviewed journals (H index = 45).

NEURINOX 

Isabelle GUILLEMAIN, is an Assistant professor at UJF and member of the Antoine Depaulis’ group at the GIN. With a PhD in Neuroscience, she has a 15-year experience with cerebral development and immunohistochemistry labeling of brain tissue. She is currently in charge of a research programme on the role of glia during epileptogenesis in both animal models: GAERS rat and MTLE mouse. Author of 8 publications in peer-reviewed journals (H index= 12).

 NEURINOX

Sophie Hamelin, is a Neurologist with a solid expertise in clinical epileptology and who recently obtained a PhD in Neuroscience on the long term consequences of hyperthermic seizures in mice. She has been hire as a Postdoctoral fellow to be in charge of tissue collection in (i) a model of hyperthermic seizures in mice and (ii) resective tissue from human patients with mesiotemporal lobe epilepsy.

 

 NEURINOX